Within the EU-funded ETERNAL project, where Asphalion serves as the regulatory partner, supporting the consortium to ensure alignment with regulatory frameworks while fostering sustainability and innovation, this case study by AstraZeneca highlights the potential of Organic Solvent Nanofiltration (OSN) membrane technology for the recovery and reuse of homogeneous catalysts in pharmaceutical manufacturing.
Homogeneous catalysts are widely used due to their efficiency, but their separation from reaction mixtures remains a key challenge. OSN offers an innovative and energy-efficient solution, enabling selective separation without phase changes or high energy input, thereby reducing environmental impact and improving process sustainability.
Key Benefits of OSN Technology:
• Energy efficiency: Operates under mild conditions without phase transitions
• Waste reduction: Minimizes solvent use and avoids complex separation steps
• Cost savings: Enables recovery and reuse of expensive catalysts
• Sustainability: Reduces environmental impact and supports greener manufacturing
The technology has demonstrated strong results, including high product recovery rates and successful reuse of catalysts across multiple cycles, while maintaining high performance. Ongoing developments aim to further optimize the process and expand its application across additional pharmaceutical syntheses.
📌 Read the full paper here: ETERNAL CASE STUDY: Membranes for Homogeneous Catalyst Recovery
For more information about the ETERNAL project, visit www.eternalproject.eu
Need help in your Regulatory projects? Contact us! [email protected]
